The COSMOS Trial

The largest clinical study investigating the long-term impact of cocoa extract supplementation and multivitamins on health

What is the COSMOS Study?

The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS):

Largest study on a bioactive
COSMOS Investigates whether cocoa extract supplementation or multivitamins can have a long-term benefit on health as we age
Initiated and led by Brigham and Women's Hospital, an affiliate of Harvard Medical School
Randomized, doubled-blinded, placebo controlled – the gold standard in research

21,000+

STUDY PARTICIPANTS comprised of Healthy Women and Men from across the U.S.

60+ Years Old

AGE OF PARTICIPANTS

5 Years

DURATION OF STUDY

500mg

OF COCOA FLAVANOLS were evaluated in the study, using a cocoa extract supplement.

COSMOS Outcomes

This first publication from COSMOS has recently been released in The American Journal of Nutrition (AJCN), the premier clinical nutrition journal in the U.S.

In this 5-year study, participants who took the cocoa extract containing 500mg of cocoa flavanols experienced 27% improvement relative to important heart health outcomes relative to those in the placebo group


27% improvement on important heart health outcomes. Including All Participants in the analysis.


39% improvement on important heart health outcomes Including only those who said they took the supplement in the analysis

Cocoa Extract Supplement Materials

The cocoa extract supplement used in the study was specifically designed to meet the rigorous requirements of human clinical research.

500mg of cocoa flavanols were evaluated in the study using cocoa extract supplementation.

COSMOS
Leadership & Partners

COSMOS is a trial that was initiated and led by scientists from Brigham and Women’s Hospital, an affiliate of Harvard Medical School, and conducted in conjunction with the Fred Hutchinson Cancer Research Center.

It was co-founded by the NIH, Mars Edge and Pfizer, whose consumer healthcare business is now part of GSK Consumer Health Care.

Mars Edge, a segment of Mars, Incorporated to supporting human health through nutrition, contributed to the study in the form of investigator-initiated grants and in-kind funding, including the provision of test materials.