The COSMOS Trial

The largest clinical study investigating the long-term impact of cocoa extract supplementation and multivitamins on health

Elderly couple dancing and laughing

What is the COSMOS Study?

The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS):

  • Largest study on a bioactive 
  • COSMOS Investigates whether cocoa extract supplementation or multivitamins can have a long-term benefit on health as we age
  • Initiated and led by Brigham and Women's Hospital, an affiliate of Harvard Medical School
  • Randomized, doubled-blinded, placebo controlled – the gold standard in research


STUDY PARTICIPANTS comprised of Healthy Women and Men from across the U.S.

60+ Years Old


5 Years



OF COCOA FLAVANOLS were evaluated in the study, using a cocoa extract supplement.

COSMOS Outcomes

Staying healthy as we age is important.

However, there is still a lot more for science to uncover on the contributors to healthy aging.

COSMOS looks to further our understanding of healthy aging, and specifically the role cocoa flavanols can play in our health.

The scale and duration of COSMOS will lead to important insights into the role that nutrition, including bioactives like flavanols, can play in heart, brain, and our general health.

The first publication from COSMOS will focus on cardiovascular health, and it will be the first of many to come.

 Learn more about the first results from the COSMOS Trial.

Diagram of the  cardiovascular system

Cocoa Extract Supplement Materials

The cocoa extract supplement used in the study was specifically designed to meet the rigorous requirements of human clinical research.

500mg of cocoa flavanols were evaluated in the study using cocoa extract supplementation.

Cocoa Flavanol Extract Powder

Leadership & Partners

COSMOS is a trial that was initiated and led by scientists from Brigham and Women’s Hospital, an affiliate of Harvard Medical School, and conducted in conjunction with the Fred Hutchinson Cancer Research Center.

It was co-founded by the NIH, Mars Edge and Pfizer, whose consumer healthcare business is now part of GSK Consumer Health Care.

Mars Edge, a segment of Mars, Incorporated to supporting human health through nutrition, contributed to the study in the form of investigator-initiated grants and in-kind funding, including the provision of test materials.

COSMOS Results Are Expected Soon!

CocoaVia™ Cardio Health

The ONLY supplement with the same ingredient as tested in COSMOS

CocoaVia™ Cardio health products contain 500 mg of cocoa flavanols - the same amount as tested in COSMOS

Available in Capsules and unsweetened Dark Chocolate Powder

Some of the inactive supplement ingredients might differ, e.g., clinical trials have specific requirements for capsule materials.